Continuous monitoring of the condition and performance of the manufacturing system on component and machine level, enables sustainable and competive manufacturing, also by introducing autonomous diagnosis capabilities and context-awareness. Detecting, measuring and monitoring the variables, events and situations will increase the performance and reliability of manufacturing systems. This involves advanced metrology, calibration and sensing, signal processing and model-based virtual sensing for a wide range of applications, e.g. event pattern detection, diagnostics, anomaly detection, prognostics and predictive maintenance.